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Aging Hearts and Arteries: A Scientific Quest by National Institute of Aging - HTML preview

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N AT I O N A L I N S T I T U T E S O F H E A LT H

N AT I O N A L I N S T I T U T E O N A G I N G

U . S . D E PA RT M E N T O F H E A LT H A N D H U M A N S E R V I C E S

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THE MISSION OF THE NATIONAL INSTITUTE ON AGING

“...the conduct and support of biomedical, social and behavioral research, training, health information dissemination, and other programs with respect to the aging process and the diseases and other special problems and needs of the aged.”

RESEARCH ON AGING ACT OF 1974, AS AMENDED IN 1990 BY P.L. 101-557

TABLE OF CONTENTS

33PrIefa

ntrce

oduction

3030 The Untapped P

The U

romise of

ntapped Promise of

the Aging

the Ag H

ing ear

H t

eart

44 A H

A ost

H

of

ost I

of nIte

n r

t c

e onnections

rconnections

33 Blood Vessels and Aging:

4 4 The I

T nt

he I r

nicat

tr e P

icat ump

e Pump

The Rest of the Journey

5 5 Anat

A omy of

natomy o the H

f

ear

the H t

eart

34

In Search of a Connection

6 6 Age,

A C

ge, hange,

C

and A

hange,

daptation

and Adaptation

35

What Happens During

7 7 In the Beg

I

inning

n the Beginning

Atherosclerosis? ✦★

7 7 The N

T

ext St

he Ne

eps

xt Steps

36

Age and Arteries

99The A

T

ging

he Ag

H

ing ear

H t

eart

38

Inside Every Artery...

38

...Time Takes its Toll

1010 The Effects of N

The Effects of or

N mal

or

Ag

mal ing

Aging

39

The Nitty Gritty of High Blood

1010 Stru

St c

r t

uur

ct al Changes

ural Changes

Pressure

1111 Hear

H t Dynamics

eart Dynamics

40

Production of Nitric Oxide in Arteries

1212 In a H

In

ear

a H t Beat

eart Beat

41

Arteries: Young and Old

1212 Hear

H t Filling

eart Filling

41

Stuck in the Middle with You

1414 Pumping A

P

t Rest

umping at Rest

42

From Balloon to Bicycle Tire

1415 Pumping Dur

The Heart: ing Ex

Yo

ercise

ung and Old

43

Can Gene Therapy be Used

16

Pumping During Exercise

to Treat Heart Problems?

1818 When the B

Whe

rain T

n the Brain alks t

T

o the Hear

alks to the H

t

eart ✦★

44

New Blood Test May Help Doctors

Detect Emerging Heart Disease

21 C

C ellular Clues

ellular Clues

45

Keeping Your Arteries Healthy

22

The Marvelous Calcium Pump

47

Exercise: Your Heart’s Best Friend

23

How a Myocyte Contracts

48

Metabolic Syndrome Accelerates

24

When a Good Pump Goes Bad

Aging of Arteries ✦★

25

Age Lengthens Action Potential

49

Healthy Foods, Healthy Arteries:

26

Free Radical Damage

Is There a Connection?

27

Nitric Oxide

27

Contractile Proteins

53

What Lies Ahead

28

Opposing Pressures: Heart Cavity

54

Glossary

Pressure vs. Aortic Pressure

58

Bibliography

28

Bigger Heart Cells...

29

...But Fewer of Them

64