Medical (Academic) Ebooks
Formulation and Evaluation of Extended Release Tablets of an Anti-retro Viral Drug
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The anti-retroviral agent is mainly absorbed from the small intestine with extended release tablets of anti-retroviral agent. This was prepared using Kollidone SR, Sodium alginate, POLYOX303 and XANTHAN GUM as retardant polymers. Various evaluation parameters like thickness, hardness, friability, weight variation and drug content of the formulations were found to be satisfactory. Among all formulations F6 and F10 appeared to have desired release pattern. But the formulation F10 more desired release pattern in with reference product. Formulation F1, F2, F7 and F8 showed lower release of drug which is due to high polymer concentration. The polymers Kollidone SR and XANTHAN GUM were important factor affecting drug release profile. The viscosity of the polymers was found to be affect the drug release and inverse relationship appeared to exit between polymer viscosity and drug release thus higher the viscosity of the polymer, lower the drug release.