Comphensive Guide to Accessory Nutrients and Essential Oils by Dr. James Meschino - HTML preview

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Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils

Accessory Nutrients and Essential Oils

Shark Cartilage

General Features

Contrary to the popular marketing campaign associated with the use of Shark Cartilage as a dietary supplement,

shark’s do get cancer, and promoting the use of Shark Cartilage based upon the notion that shark’s do not get cancer

is false and highly misleading. However, some experimental and animal studies show that a particular Shark Cartilage

extract may play role in one aspect of cancer prevention and/or treatment, but how this translates into the prevention

and/or treatment of human cancers is not well understood, although some preliminary studies have been encouraging.

At present, Shark Cartilage is one of many natural health products that continue to be studied as potential

chemopreventive and cancer treatment agents. 1, 2

Principle Active Constituents

Shark Cartilage is a type of connective tissue comprised of proteoglycans (mucopolysaccharides), protein substances,

calcium, sulfur, and collagen protein. Which of these constituents exerts anti-tumor ef ects is unknown at this time. 1

Clinical Application and Mechanism of Action

1. Cancer – Preliminary research in the 1980’s suggested that Shark Cartilage inhibits angiogenesis (the growth of

new blood vessels). Since cancer cells must build new blood vessels to provide themselves with nourishment for

growth and replication, this ef ect (anti-angiogenesis) is associated with potentially stopping the spread of cancer.

3,4,5,6,7,8,9 (see also soy isoflavones, genistein, in this document) Shark Cartilage also inhibits matrix

metalloproteases (MMP’s), which break down the ground substance between cells, and more easily permit the

spread of cancer to adjacent tissues. 4

A few preliminary studies suggest that individuals with certain cancers may benefit from Shark Cartilage

supplementation, however, well-designed research trials yielded negative results. 1,2,16,17 Nevertheless, there is

some evidence to support the use of Shark Cartilage as part of the complementary treatment for various cancers,

including lung, prostate, and breast cancer. 10,11,12,13,14,15

Double-blind trials, which are currently underway in Canada and the United States, are required to provide

conclusive evidence that Shark Cartilage is a useful adjunct in cancer treatment, but there are no significant risks

at ached to using Shark Cartilage supplementation in individual cases at this time. 1,2

2. Osteoarthritis – The use of glucosamine sulfate has been shown to be very ef ective in the treatment of

osteoarthritis. As glucosamine provides the body with raw material from which if can synthesize certain

components of joint cartilage, some individuals promote the idea that ingesting cartilage itself may act in a similar

manner as glucosamine. Presently, there are no studies of any kind to support this contention, and as is the case

with the use of chondroitin sulfate, bovine cartilage, sea cucumber, green-lippid mussel (all of which contain whole

cartilage components). It is unlikely that Shark Cartilage provides as significant an ef ect on the repair, regeneration

and preservation of joint cartilage, as does glucosamine sulfate. 2 (see glucosamine sulfate in this document)




Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils

Accessory Nutrients and Essential Oils

Dosage and Standardized Grade

Cancer Treatment: 60-100 gms per day, orally or by enema. This is a very high dose, which provides the body with 2

– 2.5 gms (2500 mg of calcium) daily. This is considered the upper limit of safe intake for calcium, although no cases

of calcium toxicity have been reported at this level of Shark Cartilage supplementation. Nevertheless, practitioners

and patients should be on the look out for any signs or symptoms of calcium toxicity when doses in this range are

being used (see calcium in this document, for signs and symptoms of toxicity). 1

Adverse Side Effects, Toxicity and Contraindications

Shark Cartilage appears to be a safe supplement. 1,2 There is one reported case of a patient who developed liver

inflammation after taking Shark Cartilage supplements, but later recovered fully after the Shark Cartilage supplement

was discontinued. 18 Therapeutic doses of Shark Cartilage may increase the potential for calcium toxicity, although

there are no reported cases of this occurring to date. 1

Drug-Nutrient Interactions

There are no well-known drug-nutrient interactions for Shark Cartilage known at this time. 1,2

Pregnancy and Lactation

During pregnancy and lactation, the only supplements that are considered safe include standard prenatal

vitamin and mineral supplements. All other supplements or dose alterations may pose a threat to the

developing fetus and there is generally insuf icient evidence at this time to determine an absolute level of

safety for most dietary supplements other than a prenatal supplement. Any supplementation practices

beyond a prenatal supplement should involve the cooperation of the at ending physician (e.g., magnesium

and the treatment of preeclampsia.)

References: Pregnancy and Lactation

1. Encyclopedia of Nutritional Supplements. Murray M. Prima Publishing 1998.

2. Reavley NM. The New Encyclopedia of Vitamins, Minerals, Supplements, and Herbs. Evans and

Company Inc. 1998.

3. The Healing Power of Herbs (2nd edition). Murray M. Prima Publishing 1995.

4. Boon H and Smith M. Health Care Professional Training Program in Complementary Medicine.

Institute of Applied Complementary Medicine Inc. 1997.

1. Healthnotes, Inc. 2001. Cartilage (Bovine and Shark)

2. Natural Product Encyclopedia. Shark Cartilage

3. Lee A, Langer R. Shark cartilage contains inhibitors of tumor angiogenesis. Science 1983;221:1185-7

4. Dupont E, Savard PE, Jourdain C et al. Antiangiogenic properties of a novel shark cartilage extract: Potential role in the tratment of

psoriasis. J Cutan med Surg 1998;2:146-52

5. Sheu JR, Fu CC, Tsai ML et al. Effect of U-995, a potent shark cartilage-derived angiogenesis inhibitor, on anti-antiogenesis and and

anti-tumor activities. Anticancer Res 1889;18:4435-41




Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils

Accessory Nutrients and Essential Oils

6. Davis PF, he Y, Furneaux RH et al. Inhibition of angiogenesis by oral ingestion of powdered shark cartilage in a rat model. Microvasc Res


7. Oikawa T, Ashino-Fuse H, Shimamura M et al. A novel angiogenic inhibitor derived from Japanes shark cartilage (I). Extraction and

estimation of inhibitory activities toward tumor and embryonic angiogenesis. Cancer Lett 1990;51:181-6

8. McGuire TR, Kazakoff PW, Hoie EB et al. Antiproliferative activity of shark cartilage with and without tumor necrosis factor-alpha in

human umbilical vein endothelium. Pharmacotherapy 1996;16:237-44

9. Lee A, Langer R. Shark cartilage contains inhibitors of tumor angiogenesis. Science 1983 1983;221:1185-7

10. Riviere M, Latreille J, Falardeau P et al. AE-941 (Neovastat), an inhibitor of angiogenesis: phase I/II cancer clinical trial results. Cancer

invest 1999;17(suppl1):16-7

11. Jamali M-A, Riviere M, Falardeau P et al. Effect of AE-941 (neovastat), an angiogenesis inhibitor, in the Lewis lung carcinoma metastatic

model, efficacy, toxicity prevention and survival. Clin Invest Med 1998;(suppl):S16

12. Riviere M, Falardeau P, Latreille J et al. Phase I/II lung cancer clinical trial results with AE-941 (neovastat), an inhibitor of angiogenesis.

Clin Invest Med 1998;(suppl):S14

13. Riviere M, Alaoui-Jamali M, Falardeau P et al. Neovastat: an inhibitor of angiogenesis with anti-cancer activity. Presented at: American

Association for Cancer Research Annual Meeting 39 March 28-April 1 1998;New Orleans, LA

14. Blaseck J, Alaoui-Jamali M, Wang T et al. Oral administration of Neovastat inhibits tumor progression in animal models of progressive

tumor growth and metastasis. Int J Oncol 1997;11(suppl):934

15. Dupont E, Alaoui-Jamali M, Wang T et al Angiostatic and antitumoral activity of AE-941 (Neovastat), a molecular fraction derived from

shark cartilage. Presented at: American Association for Cancer Research Annual Meeting 38 April 12-16 1997;San Diego CA

16. Horsman MR, Alsner J, Overgaard J. The effect of shark cartilage extractrs on the growth and metastatic spread of the SCCVII

carcinoma. Acta Oncol 1998;37:441-5

17. Miller DR, Anderson GT, Stark JJ et al. Phase I/II trial the safety and efficacy of shark cartilage in the treatment of advanced cancer. J

Clin Oncol 1998;16:3649-55

18. Ashar B, Vargo E. Shark cartilage-induced hepatitis. Ann Intern Med 1996;125:780-1




Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils

Accessory Nutrients and Essential Oils

Soy and Soy Extract

James Meschino DC, MS,ND

General Features

Soybeans contain a variety of biologically active components that are associated with the prevention of certain

cancers, detoxification, bone density support, cholesterol lowering and cardiovascular health, prevention of prostate

enlargement and antioxidant function.

Principle Active Constituents

Some of their more potent bioactive constituents include:



Phenolic acids


Protease inhibitors

Phytic acid 1,2,3,4

Clinical Application and Mechanism of Action