Comphensive Guide to Accessory Nutrients and Essential Oils HTML version

Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
Malic Acid
General Features
Malic Acid is synthesized in humans as one of the steps in the Kreb’s cycle during the production of ATP, which is the
body’s primary source of energy. 1 It occurs in high concentrations in apples and is often referred to as apple acid. In
food processing it is used to acidify wines, acid drinks, fruit juices, soda water and various soft drinks. Malic Acid is
also used in cosmetic products to adjust the pH of the product and to act as a moisturizing agent, often in the form of
sodium malate. 2
Clinical Application and Mechanism of Action
1. Fibromyalgia - Malic Acid supplementation in combination with magnesium supplementation has been shown to
improve fibromyalgia in a six-month, double-blind, cross-over trial, involving 24 fibromyalgia patients. In this study,
the treatment group demonstrated a significant reduction in the severity of pain and tenderness and in some
psychological symptoms associated with their condition, during the period they ingested 1200-2400 mg of Malic
Acid and 300-600 mg of magnesium per day. During the cross-over period, when placed on the placebo, their
muscle pain scores rose from 6.8 to 21.5 within two days, in the six patients comprising this sub-group. However,
in a shorter trial of only four weeks, the combination of Malic Acid (1200 mg) and magnesium (300 mg) was not
effective in reducing pain in a double-blind, cross-over trial of patients with fibromyalgia. This may indicate that a
longer period of treatment is required to realize improvement in these cases. 3,4
2. Chronic Fatigue Syndrome - It is speculated that Malic Acid supplementation in combination with magnesium
supplementation may be helpful in the treatment of chronic fatigue syndrome. There is one published report to
support this contention, but better controlled studies are required to substantiate this application. However, chronic
fatigue syndrome is similar in nature to fibromyalgia, thus practitioners may wish to utilize this intervention on a
therapeutic trial basis. 5
Dosage and Standardized Grade
Fibromyalgia (and Chronic Fatigue Syndrome) - Malic Acid, 600 mg, twice per day and magnesium, 150 mg, twice per
day (up to 2400 mg of Malic Acid and 600 mg of magnesium have been used safely). 3,4
Adverse Side Effects, Toxicity and Contraindications
Current research does not indicate any adverse side effects from the use of Malic Acid at the above-cited levels of
intake. 6
Drug-Nutrient Interactions
At present there are no known drug-nutrient interactions with Malic Acid. 6