Comphensive Guide to Accessory Nutrients and Essential Oils HTML version
Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
Coenzyme Q10 (Ubiquinone)
CoQ10 is an essential component of the electron transfer system in the mitochondria. More specifically, it functions to
shuttle hydrogen electrons from NAD to cytochrome b, facilitating the release of energy required to recouple ADP with
inorganic phosphate in the synthesis of ATP. As such, CoQ10 is an integral part of the bioenergetic system that
enables cells to produce adequate amounts of ATP through aerobic pathways. ATP is the primary fuel required to
power the body’s metabolic reactions, maintain optimal function of cells and sustain life. A deficit in ATP synthesis can
compromise any number of energy-dependent cellular functions and hasten the onset of dysfunction and if severe
enough, cell death.
Although the body can synthesize CoQ10, deficiency states of CoQ10 tend to exist and are associated with various
health conditions. Moreover, supplementation studies with CoQ10 have been shown to effectively treat and sometimes
reverse a number of these conditions.
There is evidence that a decline in CoQ10 synthesis occurs with aging, predisposing individuals to a number of CoQ10
deficiency-related disorders and diseases.
Professor F.L. Crane and his colleagues at the University of Wisconsin first discovered CoQ 10 in 1957. Since then, Dr,
Karl Folkers at the University of Texas (Austin) is most responsible for the ongoing research on CoQ10.1-4
Coenzyme Q10 is also a fat soluble antioxidant, which has been shown to reduce oxidation of LDL-cholesterol and the
mitochondrial DNA.5,6 CoQ10 supplementation has been shown to modulate immune system function, enhancing
levels of immunoglobulin G (IgG), in the serum of patients provided with 60 mg CoQ10 per day.7
The average person may consume about 5 mg per day of CoQ10 from foods, with the main sources being meat, fish,
soybeans and some vegetable oils. Clinical Coenzyme Q10 studies have involved daily supplemental intake levels
ranging from 60 mg to 300 mg per day; far greater than food alone can provide.8
Supplementation Studies and Clinical Applications
1. Cardiovascular Disease
Biopsy results from heart tissue in patients with various cardiovascular diseases (especially congestive heart failure)
show a deficiency in CoQ10 in 50 to 75 percent of cases. Low blood levels of CoQ10 are also a consistent finding in the
majority of these patients.9-12
Supplementation studies with patients suffering from various cardiomyopathies (i.e. ischemic cardiomyopathy, dilated
cardiomyopathy, heart valve disorders) and congestive heart failure have demonstrated significant improvement in
heart function (according to the New York Heart Association functional scale) in a high percentage of cases.
Many patients in these studies have been able to reduce the number of cardiac drugs required (1-3 medications
reduced in 43 percent of CoQ10 supplemented patients in one study of 424 patients, over an eight year period).
Heart function parameters monitored have included left ventricular wall thickness, mitral valve inflow slope, and
Congestive Heart Failure - Several controlled studies using Coenzyme Q10 supplementation in patients with congestive
heart failure have demonstrated significant improvement in cardiac ejection fraction, reduced shortness of breath, and
increased muscle strength. Other studies have demonstrated increased stroke volume and cardiac index, improved
survival and improved quality of life, in general. Of great significance is the fact that when patients discontinue CoQ10
supplementation, cardiac function deteriorates. Thus, CoQ10 needs to be a lifelong intervention in these cases.16,17,18