Comphensive Guide to Accessory Nutrients and Essential Oils HTML version

Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
Lipoic Acid (Thioctic Acid)
General Features
Lipoic Acid is a sulfur-containing, vitamin like substance. Although the body manufactures Lipoic Acid, under certain
circumstances, supplementation has been shown to be beneficial.
Lipoic Acid functions as a co-enzyme (with vitamin B1 and niacin) in the conversion of pyruvate to acetyl co-enzyme A,
thus it is essential for aerobic energy metabolism.1
Lipoic Acid is also a water soluble and fat soluble antioxidant.2 With coenzyme Q10 and vitamin E, it appears to protect
mitochondrial DNA from the damaging effects of oxygen-free radicals; providing a potential anti-aging effect in
preserving mitochondrial DNA structure and function.3
Supplementation Studies
1. Diabetic Neuropathy
In Germany Lipoic Acid is approved as a drug for the treatment of diabetic neuropathy. Its therapeutic effects
appear to be mediated through its antioxidant effects. However, it has also been shown to improve blood glucose
metabolism, reduce glycosylation of amino acids (i.e. hemoglobin glycosylation), improve blood flow to peripheral
nerves and stimulate regeneration of nerve fibers in diabetic subjects. Lipoic Acid enhances insulin sensitivity in
diabetics, which explains its beneficial effects on blood glucose regulation and reduced blood amino acid
For diabetic neuropathy studies reveal that combining 600 mg of Lipoic Acid daily, with 100 mcg of selenium, or
1,200 I.U. of vitamin E, produced significant results over the placebo.4-9
Lipoic Acid supplementation in AIDS patients has been shown to increase plasma ascorbic acid, glutathione, and
T-helper lymphocytes and T-helper/suppressor cell ratio in a significant number of patients. All of these factors are
important biomarkers in AIDS progression, suggesting that Lipoic Acid supplementation may help slow the
progression of HIV and AIDS. The daily dosage was 1,500 mg, three times daily.
Studies indicate that Lipoic Acid inhibits HIV replication by reducing the activity of reverse transcriptase (the
enzyme responsible for manufacturing the virus from the DNA of lymphocytes) and inhibits the activation in HIV that
leads to viral replication.10,11,12
3. Other Applications
Lipoic Acid supplementation may be considered in liver cirrhosis and other liver damage, heart disease, cataracts,
heavy metal toxicity and support for detoxification and antioxidant functions.
1. Diabetic Neuropathy: 300-600 mg daily1,3
2. AIDS (HIV): 1,500 mg three times daily
3. General Support: 20 – 50 mg daily