Comphensive Guide to Accessory Nutrients and Essential Oils HTML version

Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
General Features
Gamma-Oryzanol (esters of ferulic acid) is a growth-promoting substance in grains and is isolated from rice bran oil for
use as a supplement. In 1970 Gamma-Oryzanol was approved as a medicinal treatment to lower cholesterol and
triglycerides (Japan).1 As far back as the 1960’s, Gamma-Oryzanol was shown to be effective in the treatment of
menopausal symptoms, including hot flashes, and subsequent studies have supported these findings.1
Orally administered Gamma-Oryzanol is converted in the body to free ferulic acid.2
Supplementation Studies and Clinical Applications
1. Menopausal Symptoms
Supplementation with Gamma-Oryzanol (150 mg, twice per day) has been shown to reduce the secretion of
leutinizing hormone (LH) by the pituitary and promote endorphin release by the hypothalamus.3 Hot flashes and
other menopausal symptoms (profuse sweating, mood changes) result indirectly from the over-secretion of
leutinizing hormone, which is attempting to initiate the start of another ovulatory cycle. The lack of response by the
immature egg cells in the ovaries in menopause results in an over-secretion of FSH (follicle stimulating hormone)
and LH by the pituitary, contributing to the onset of hot flashes and related symptoms.4
Clinical trials involving menopausal women and women who had their ovaries surgically removed, have revealed
that 67-85 percent of women treated with Gamma-Oryzanol have experienced a significant reduction in
menopausal symptoms.5,6
2. Cholesterol and Triglyceride Lowering (Hypo-Lipidemic Effects)
A number of clinical traits reveal that 300 mg per day of Gamma-Oryzanol supplementation can lower cholesterol
by 8-12 percent and triglycerides by approximately 15 percent in subjects with elevated lipid levels.7,8,9
Gamma-Oryzanol supplementation increases the conversion of cholesterol to bile acids, increases bile acid
excretion, and inhibits the absorption of cholesterol from the intestinal tract to the bloodstream.10,11
These are important considerations for post menopausal women as heart disease is the most common cause of
death in women over 50 years of age in North America. The decline in circulating estrogen levels with menopause
predisposes postmenopausal women to a rise in blood cholesterol and the development of atherosclerosis. This is,
in part, due to the fact that estrogen increases the number of LDL- cholesterol receptors on body cells, enabling the
body to remove LDL-cholesterol from the bloodstream very effectively.12,13
Menopausal Symptoms: 300 mg per day, taken in divided doses (ie. 150 mg, twice per day)
Hypolipidemic Effects: 300 mg per day, taken in divided doses (i.e. 150 mg, twice per day)
Adverse Side Effects and Toxicity
Toxicity studies on animals demonstrate that it is a very safe compound. No significant side effects have been
reported in human trials or experimental studies.14,15