Comphensive Guide to Accessory Nutrients and Essential Oils HTML version

Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
Dimethylaminoethanol (DMAE)
General Features
Dimethylaminoethanol (DMAE), also known as Deanol, is a naturally occurring substance that is structurally similar to
choline, a nutrient used by the brain to make the memory chemical acetylcholine. Studies on DMAE date back to the
1950’s and indicate that DMAE may be of value in the treatment of autism and for children with hyperkinetic behavior
and learning disorders. Initially, it was claimed that DMAE could increase brain levels of acetylcholine based upon
animal experimentation, but concrete evidence is lacking to support this effect in humans.1,2,3,7
Principle Active Constituents
2-Dimethylaminoethanol (DMAE) is the active ingredient and was marketed as a prescription drug in the 1960’s and
1970’s under the name Deanol.4,5 DMAE is now a natural health product and is no longer categorized as an over-the-
counter or prescription drug.9
Clinical Application and Mechanism of Action
1. Attention Deficit Disorder, Childhood Hyperactivity and Autism
Some studies have shown that DMAE can improve attention span and decrease irritability in children affected by
attention deficit problems and hyperactivity disorders.4, In one study involving 74 children referred for treatment for
childhood hyperactivity, 500 mg of Deanol per day was shown to be as effective or better than the drug
methylphenidate with respect to improved learning capability and correction of behavior disorders.4
A 1988 survey by the Institute for Child Behavior in San Diego revealed that DMAE was the second most popular
supplement used by parents to help their children with autism, after vitamin B6 and magnesium, with two parents
indicating improvement for every one parent reporting a worsening of the condition from DMAE supplement use.1
2. Dementia and Alzheimer’s disease
Several studies have tested the use of DMAE in Alzheimer’s and dementia patients. Overall, results do not show
an improvement in memory or cognitive function, but do suggest that it may reduce depression, irritability and
anxiety, and increase motivation-initiative.3,1,8
Dosage and Standardized Grade
1. Childhood Attention Deficit Disorder, Hyperactivity And Autism - 500 mg per day has been used in various studies,
but 100 mg once or twice per day can be used. DMAE’s effects generally develop slowly over a period of two to
four weeks.4,9
2. Alzheimer’s disease and Dementia - Doses up to 600 mg, three times per day, have been used without untoward
side effects.3 However, some patients have reported increased confusion and drowsiness in trials with Alzheimer’s
3. General Wellness - Doses as low as 10 to 20 mg per day have been used to produce a pleasant degree of central
nervous system stimulation within 7-10 days. One study on medical students demonstrated greater daytime
energy, attentiveness, sounder sleep and better ability to concentrate than the placebo group, when given a daily