As a principle donor of methyl groups (CH3) to various reactions, SAM is necessary for the synthesis of
phospholipids (phosphatidylcholine, phosphatidylserine) and neurotransmitters. SAM supplementation in
depressed or anxious patients has resulted in increased levels of serotonin, dopamine and phosphatidylserine. It
improves binding of neurotransmitters to receptor sites, and af ects brain cell membrane fluidity, resulting in
significant
clinical
improvement
in
depression
and
anxiety.2,3,6,7,8
A number of excellent clinical trials have demonstrated the value of SAM as a natural biochemical intervention in
depression. The typical dosage is 400 mg, three to four times per day (studies include general depression and
post-partum depression).9-13
Alzheimer’s disease patients have been shown to have low levels of SAM and may therefore, benefit from its
administration.2,3