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Comphensive Guide to Accessory Nutrients and Essential Oils


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Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
Quercetin
General Features
Quercetin is a flavonoid that serves as the backbone for many other flavonoids in nature, including the citrus flavonoids
rutin, quercitin, and hesperidin. These derivates differ from Quercetin in that they have sugar molecules attached to
their Quercetin backbone. Experimental studies reveal that many medicinal plants owe much of their biological activity
to their high Quercetin content.1
This water-soluble pigment has been shown to inhibit histamine release at therapeutic doses, making it an attractive
agent in the management of some allergic conditions, such as hay fever. It also demonstrates impressive anti-
inflammatory and antioxidant properties, and like some other flavonoids (e.g. genistein, diadzein), appears to possess
phytoestrogen effects. Under experimental conditions, its phytoestrogen effects have been shown to inhibit the
proliferation of human breast cancer cells in test tube experiments. In one human trial, Quercetin supplementation
demonstrated improvement in prostatitis, with 67% of patients experiencing significant improvement in the Quercetin
group compared to only 20% of patients reporting improvement in the placebo group. This benefit may be due to its
phytoestrogen activity and/or its anti-inflammatory properties.
Experimental studies also reveal that Quercetin may help to prevent cataracts in diabetics, by inhibiting the enzyme
that forms sorbitol (aldose reductase) in the lens of the eye.2,3
Clinical Applications and Mechanism of Action
1. Anti-Inflammatory
Quercetin inhibits the manufacture and release of histamine and other allergic/inflammatory mediators, which gives
Quercetin supplementation application in a variety of inflammatory and allergic reactions (arthritis, joint
inflammation, asthma, hay fever, lupus).4-12
2. Diabetic Cataracts
Quercetin inhibits the aldose reductase enzyme, which converts glucose into sorbitol. Sorbitol build up in the lens
of the eye (secondary to diabetes and hyperglycemia) is involved in the development of cataracts.
Elevated sorbitol may also contribute to the development of diabetic neuropathy and retinopathy. Thus, Quercetin
may be beneficial in diabetes management for a number of reasons.13,14 Animal studies reveal that Quercetin
effectively delays the onset of cataracts in diabetic animals.14
3. Anti-Tumor
Many flavonoids inhibit tumor formation, but Quercetin has demonstrated a very consistent effect in this regard.
Under experimental conditions, Quercetin demonstrates a significant antiproliferative effect in regards to squamous
cell carcinoma, leukemia, and cancers of the breast, ovaries, colon, rectum and brain.15-18 It is thought that
Quercetin down-regulates enzymes that control the rate of cellular division (i.e. protein kinase, DNA-topoisomerase,
ornithine decarboxylase), in addition to its mild phytoestrogen effects.2,3,19,20
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