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Comphensive Guide to Accessory Nutrients and Essential Oils

Meschino Health Comprehensive Guide to Accessory Nutrients and Essential Oils
Accessory Nutrients and Essential Oils
S-Adenosylmethionine (SAM)
General Features
S-Adenosylmethionine (SAM) is an important methyl donor (CH3) in the transmethylation reactions required for the
synthesis of DNA bases, creatine, glutathione, neurotransmitters (i.e. melatonin), phosphatidylcholine, and for liver
detoxification reactions.
In the body, SAM is synthesized from methionine and ATP. Methionine, required for the synthesis of SAM, is obtained
from diet, or produced from homocysteine, which accepts a methyl group (CH3) from vitamin B12; that was transferred
to vitamin B12 from folic acid originally. Thus the synthesis of methionine and SAM are primarily dependant upon an
adequate nutritional status of folic acid and vitamin B12.1,2,3
Curiously, high doses of methionine do not increase levels of SAM, but rather are associated with some degree of
toxicity.4 The most natural way to optimize endogenous synthesis of S-Adenosylmethionine is to ensure adequate
intake of folic acid, vitamin B12 and protein.3 Of clinical significance is the fact that SAM supplementation on its own
has been shown to provide significant results in depression, osteoarthritis, fibromyalgia and liver disorders.5
Clinical Applications and Mechanism of Action
1. Depression, Anxiety and Dementia
As a principle donor of methyl groups (CH3) to various reactions, SAM is necessary for the synthesis of
phospholipids (phosphatidylcholine, phosphatidylserine) and neurotransmitters. SAM supplementation in
depressed or anxious patients has resulted in increased levels of serotonin, dopamine and phosphatidylserine. It
improves binding of neurotransmitters to receptor sites, and affects brain cell membrane fluidity, resulting in
significant clinical improvement in depression and anxiety.2,3,6,7,8
A number of excellent clinical trials have demonstrated the value of SAM as a natural biochemical intervention in
depression. The typical dosage is 400 mg, three to four times per day (studies include general depression and
post-partum depression).9-13
Alzheimer’s disease patients have been shown to have low levels of SAM and may therefore, benefit from its
2. Osteoarthritis
SAM has demonstrated impressive results in the treatment of osteoarthritis. SAM is required for the synthesis of
cartilage components and appears to exert pain-relieving and anti-inflammatory properties.14,15
At least 21,524 patients with osteoarthritis have participated in clinical trials using SAM supplementation. Even
when tested against commonly used anti-inflammatory drugs (i.e. Advil, Motrin, Nuprin, Naproxen) SAM
supplementation has provided significant relief of osteoarthritic symptoms and improved joint function and quality of
life. An MRI (magnetic resonance imaging) study demonstrated increased cartilage formation in 14 patients with
osteoarthritis of the hands, given SAM vs. the placebo. Unlike non-steroidal anti-inflammatory drugs SAM is not
harmful to the intestinal tract, kidney or liver. In fact, it is used to support liver detoxification functions in anti-aging
In the above studies, the typical dosage of SAM was 400 mg, three times per day.